Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in Tuberculosis
نویسندگان
چکیده
منابع مشابه
Host-Directed Therapies for Tuberculosis.
Host-directed therapies are a relatively new and promising approach to treatment of tuberculosis. Modulation of specific host immune pathways, including those that impact inflammation and immunopathology, can limit mycobacterial infection and pathology, both in cell culture and in animal models. This review explores a range of host pathways and drugs, some already approved for clinical use that...
متن کاملHost-Directed Therapeutics as a Novel Approach for Tuberculosis Treatment.
Despite significant efforts to improve the treatment of tuberculosis (TB), it remains a prevalent infectious disease worldwide owing to the limitations of current TB therapeutic regimens. Recent work on novel TB treatment strategies has suggested that directly targeting host factors may be beneficial for TB treatment. Such strategies, termed host-directed therapeutics (HDTs), focus on host-path...
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Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease progression may accelerate discovery of adjunct host-directed therapies (HDTs...
متن کاملHost-Pathogen Interactions in Tuberculosis
My presentation will focus on host-cell pathogen interactions in tuberculosis. However, I would first like offer a brief introduction to the tuberculosis disease. I believe it is important to remember that merely an estimated 5-10% of individuals exposed or infected with the Mycobacterium tuberculosis bacteria actually develop tuberculosis. In other words, the human population, as a whole, is e...
متن کاملHost–Pathogen Interactions in Tuberculosis
The development of massively parallel DNA sequencing is revealing the scale of mammalian bacterial colonization and suggests that Homo sapiens is colonized by between 103 and 104 bacterial phylotypes. The understanding of the complexity of host-bacterial interactions could explain why only a relatively tiny number of bacteria causing human diseases (Keijser et al., 2008; McKenna et al., 2008; H...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.01553